The Effects of Propofol on Cerebral and Spinal Cord Blood Flow in Rats

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Abstract
Entanyl. Rats in the fentanyl/N2O group (control, n = 13) received 70% N2O in O2 plus fentanyl (bolus: 10 μg/kg; infusion: 25 μg·kg−1·h−1). Rats in the low-dose propofol group (n = 10) received 30% O2 in air and propofol infusion (0.5 mg·kg−1·min−1). Rats in the high-dose propofol group (n = 8) received 30% O2 in air and propofol infusion (2.0 mg·kg−1·min−1). Blood flow autoregulation was tested by manipulating the mean arterial blood pressure with phenylephrine infusion or trimethaphan infusion and blood withdrawal by measuring CBF and SCBF using radioactive microspheres. Arterial blood gases, pHa, and skull temperature were controlled. Cerebral and spinal cord vasculature showed autoregulation in all treatment groups with a pressure range of 50–140 mm Hg. Within this pressure range, when compared to fentanyl/N2O, propofol decreased cortical CBF 60% (P < 0.001), Subcortical CBF 40% (P < 0.001), midbrain blood flow 30% (P < 0.001), and SCBF 20% (P < 0.05). These results indicate that propofol maintains CBF and SCBF autoregulation. Address correspondence and reprint request to Christian Werner, MD, Department of Anesthesiology, University Hospital Eppendorf, Martinistreet 54, 2000 Hamburg 20, Germany. This work was presented in part at the Annual Meetings of the American Society of Anesthesiologists, Las Vegas, 1990, and the Society of Neurosurgical Anesthesia and Critical Care, Las Vegas, 1990. Accepted for publication January 8, 1993. © 1993 International Anesthesia Research Society...

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