CATABOLIC EFFECT OF DIHYDROTACHYSTEROL AND ANABOLIC ACTION OF 17-ETHYL-19-NORTESTOSTERONE ON THE UPTAKE OF RADIOSULPHUR IN A HEALING FRACTURED BONE OF THE RAT
- 1 May 1958
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 28 (1) , 119-123
- https://doi.org/10.1530/acta.0.0280119
Abstract
The selec-tive binding of S35 by the healing fractured bones of rats was used to determine the catabolic effect of dihydrotachysterol (AT-10) and the anabolic action of 17-ethyl-19-nortestosterone (Nilevar). In the dosages used, AT-10 lowered the uptake of S35 by fractured bone, expressed as the ratio of the radioactivity of fractured (F) and intact (I) humeri 3 weeks after fracture, from 2.03 in control animals to 0.87. When Nilevar was administered in an attempt to curb the effect of AT-10, the F/I ratio was 1.65. It is concluded that AT-10 blocks and 17-ethyl-19-nortestosterone stimulates the synthesis of mucopolysaccharides in newly formed collagen tissue. 17-ethyl-19-nortestosterone also protects this tissue against catabolic effect of AT-10.Keywords
This publication has 1 reference indexed in Scilit:
- EFFECT OF VARIOUS HORMONES UPON THE SYNDROME OF DIHYDROTACHYSTEROL (AT-10) INTOXICATIONActa Endocrinologica, 1957