Pathology of Pulseless Disease

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Abstract
Pathologically and morphologically, this disease is mesarteritis of the aortic arch and larger stem arteries branching out from the aorta, which shows granulomatous or diffuse productive inflammation of media and adventitia by way of vasa vasorum, complicated with a marked secondary juvenile arteriosclerosis and culminating in severe stenosis of the arterial lumina. It should be named "truncoarteritis productiva granulomatosa." The cause is not established, although some cases show evidences suggestive of a tuberculous nature. The fact that 18 out of 21 cases proved to be young women or female infants seems to suggest that age and sex factors are concerned with the development secondary juvenile arteriosclerosis.

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