Release of corrosion products by F‐75 cobalt base alloy in the rat. III: Effects of a carbon surface coating

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Abstract
A pyrolytic carbon coating was applied to F‐75 chromium‐cobalt‐molybdenum alloy in an effort to reduce the release of corrosion products in vivo. After intramuscular implantation in the rat, a complex pattern of serum and urine concentration elevations of chromium, cobalt, and nickel was seen. The carbon‐coated implants released more chromium and cobalt than uncoated controls, as seen by significantly elevated metal concentrations in serum and urine. Animals receiving carbon‐coated implants showed a high rate of recurrent implant site inflammation. Neoplastic infiltration of the implant site occurred in 3 out of 24 animals with coated implants, but not in any of the 16 animals which received either uncoated F‐75 microsphere or poly(ethylene) particulate implants.