Simple centromere, complex kinetochore
Open Access
- 15 April 2002
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 157 (2) , 199-203
- https://doi.org/10.1083/jcb.200201052
Abstract
Although the budding yeast centromere is extremely short (125 bp) compared to those of other eukaryotes, the kinetochore that assembles on this DNA displays a rich molecular complexity. Here, we describe recent advances in our understanding of kinetochore function in budding yeast and present a model describing the attachment that is formed between spindle microtubules and centromeric DNA. This analysis may provide general principles for kinetochore function and regulation.Keywords
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