Cholesterol as a target for toxins
- 1 April 1990
- journal article
- review article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 10 (2) , 127-130
- https://doi.org/10.1007/bf01116571
Abstract
A mechanism is proposed for the way in which cholesterol facilitates channel formation by polyene antibiotics and bacterial protein toxins. Central elements of the model are: (i) interactions between the ring system of the sterol and rigid elements of the polyene or toxin molecule, and (ii) the specific orientation of cholesterol within the membrane.Keywords
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