Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets
Top Cited Papers
Open Access
- 1 January 2009
- journal article
- review article
- Published by Springer Nature in BMC Genomics
- Vol. 10 (1) , 403
- https://doi.org/10.1186/1471-2164-10-403
Abstract
Human peripheral blood monocytes (Mo) consist of subsets distinguished by expression of CD16 (FCγRIII) and chemokine receptors. Classical CD16- Mo express CCR2 and migrate in response to CCL2, while a minor CD16+ Mo subset expresses CD16 and CX3CR1 and migrates into tissues expressing CX3CL1. CD16+ Mo produce pro-inflammatory cytokines and are expanded in certain inflammatory conditions including sepsis and HIV infection.This publication has 107 references indexed in Scilit:
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