The effect of donor age on the in vitro life span of cultured human arterial smooth-muscle cells
- 1 November 1978
- journal article
- research article
- Published by Springer Nature in In Vitro Cellular & Developmental Biology - Plant
- Vol. 14 (11) , 951-955
- https://doi.org/10.1007/bf02616126
Abstract
Summary The number of population doublings of cultured human arterial smooth-muscle cells decreased as a function of donor age (0.5 to 82 years). Cells from older donors als showed longer latent periods for outgrowth from explants. These results extend other comprable observations with human skin fibroblasts to another cell type, and may have relevance to the pathogenesis of atherosclerosis with aging in vivo.Keywords
This publication has 18 references indexed in Scilit:
- The serial cultivation of human diploid cell strainsPublished by Elsevier ,2004
- The limited in vitro lifetime of human diploid cell strainsPublished by Elsevier ,2004
- Chronologic and Physiologic Age Affect Replicative Life-Span of Fibroblasts from Diabetic, Prediabetic, and Normal DonorsScience, 1978
- Testing the Commitment Theory of Cellular AgingScience, 1977
- Tissue-specific differences in cultured human diploid fibroblastsExperimental Cell Research, 1977
- The Pathogenesis of AtherosclerosisNew England Journal of Medicine, 1976
- Lipoprotein Uptake and Metabolism by Rat Aortic Smooth Muscle Cells in Tissue CultureCirculation Research, 1974
- Life histories of hyperplastoid cell lines from aorta and skinExperimental and Molecular Pathology, 1973
- Long-Term Culture of Human Adult Liver Cells: Morphological Changes Related to in vitro Senescence and Effect of Donor’s Age on Growth PotentialGerontology, 1973
- Latent Period for Outgrowth of Human Skin Explants as a Function of AgeJournal of Gerontology, 1970