Pharmacokinetics of gentamicin in patients undergoing continuous ambulatory peritoneal dialysis
- 1 April 1981
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 19 (4) , 605-607
- https://doi.org/10.1128/aac.19.4.605
Abstract
Teh pharmacokinetics of gentamicin were studied in seven chronic renal failure patients undergoing continuous ambulatory peritoneal dialysis. Patients received 100 mg of gentamicin in 2 liters of dialysate during an initial pass, and serum and dialysate samples were collected for gentamicin determination. Approximately 49% of the amount introduced into the peritoneal cavity was absorbed systemically during a 6-h cycle. Subsequent clearance of gentamicin from the serum occurred slowly with an elimination half-life of 36 h. Dialysis clearance of gentamicin during continuous ambulatory peritoneal dialysis was 2.94 ml/min.This publication has 3 references indexed in Scilit:
- Peritonitis During Continuous Ambulatory Peritoneal DialysisAnnals of Internal Medicine, 1980
- Continuous Ambulatory Peritoneal DialysisAnnals of Internal Medicine, 1978
- Kinetic model for gentamicin dosing with the use of individual patient parametersClinical Pharmacology & Therapeutics, 1977