THE BLOOD URIC ACID AND ALLANTOIN OF THE RAT AFTER NEPHRECTOMY AND HEPATECTOMY

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Abstract
The blood uric acid and allantoin concn. of 72 rats was detd. It was found that the mean allantoin concn. was 2.1 mg. % and the median value was 1.8 mg. %. Forty two rats were bilaterally nephrectomized and it was found that no significant change occurred in the blood uric acid content even after 48 hrs. The blood allantoin however increased from a pre-operative level of 2.1 mg. %-50 mg. %, 72 hrs. after nephrectomy. Eight rats were hepatectomized. Following the hepatectomy, the blood uric acid rose from a pre-operative level of 1.6 mg.%-14 mg. %, 6 hrs. after hepatectomy. The blood allantoin content however did not change after hepatectomy. Three rats were nephrectomized, then hepatectomized 15 hrs. after the nephrectomy. It was found that following nephrectomy, the allantoin content of the blood steadily increased from 1.9 mg.% before nephrectomy to 24 mg. % just before hepatectomy, and after the latter procedure, the blood allantoin failed to rise further. On the other hand, the blood uric acid did not change following nephrectomy but after hepatectomy, it rose from 1.2 mg.%-13 mg. %, 6 hrs. after hepatectomy. Evidence was marshalled to support the concept that all uric acid not excreted in the urine is converted entirely to allantoin in the rat and that the liver is the site of this conversion.

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