Effects of seven different oestrogen sulphates on uterine growth and on progesterone receptor in the foetal uterus of guinea pig after administration to the mother

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Abstract
The biological effect of 7 different estrogen sulfates: estrone-3-sulfate (E1-3-S), estradiol-3-sulfate (E2-3-S), estradiol-17-sulfate (E2-17-S), estradiol-3,17-disulfate (E23,17-DS), estriol-3-sulfate (E3-3-S), estriol-17-sulfate (E3-17-S), estriol-3,16-17-trisulfate (E3-3,16,17-TS), was studied in the fetal uterus of guinea pig (55-65 days of gestation) after s.c. administration for 3 consecutive days of each sulfate to the mother. On day 4, two response parameters were investigated, the uterotrophic effect and the action on the progesterone receptor. The monosulfates at the C3 position of the estrogens (E1-3-S, E2-3-S and E3-3-S) provoked an increase in uterine weight of 1.9-2.4 times in relation to the nontreated animals. These estrogen sulfates also very significantly stimulated the number of progesterone specific binding sites, 7-10 times in relation to the nontreated animals. When the sulfate was at C17 of the estrogens (E2-17-S, E3-17-S, E2-3,17-DS, E3-3,16,17-TS), very little or no effect on the fetal uterus was observed on the 2 parameters studied. Estrogen (estrone, estradiol, estriol) sulfates in position C3 can be involved in the biological response to the hormone. Apparently, the effect is carried out after the hydrolysis of the sulfate. Sulfates in C17 are not hydrolyzed and no significant biological effects were observed in the uterine growth or in the progesterone receptor.