Enhanced vascular reactivity to norepinephrine in salt-sensitive patients with hypertension.

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Abstract
Twenty patients with hypertension were studied under diets containing low and high salt to identify factors which might be involved in elevating blood pressure under Na-loading. They were classified as salt-sensitive (SS) and nonsalt-sensitive (NSS) according to the presence or absence of > 10% increases in mean blood pressure when a low salt diet was replaced by a high salt diet. During high-Na intake, the SS patients showed reduced urinary excretion of Na and elevated plasma levels of aldosterone as compared with plasma renin activity. The SS patients also showed an enhanced pressor response to norepinephrine under both low-Na and high-Na diets. Apparently, the Na retention, which is probably related to nonsuppressed levels of PAC [plasma aldosterone concentration] under Na-loading, is 1 factor in elevating blood pressure in the SS patients. The enhanced pressor response to norepinephrine seems to contribute, in part, to elevation of blood pressure in the SS patients under salt-loading.

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