Source of Abnormal Bile in Patients with Cholesterol Gallstones

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Abstract
Cholesterol gallstones are formed when excess cholesterol precipitates from bile supersaturated with cholesterol. Either the gallbladder, by alteration of the composition of normal hepatic bile, or the liver, by production of an abnormal bile, could be the source of the bile supersaturated by cholesterol. Since cholesterol gallstones are very prevalent among American Indians of the Southwest, we analyzed their gallbladder and hepatic bile to determine which organ is responsible for the disease.