Carbon-13 nuclear magnetic resonance assignments and biosynthesis of aflatoxin B1 and sterigmatocystin

1 January 1976

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1

No. 11,p. 1182-1189
https://doi.org/10.1039/p19760001182

Abstract

The ¹³C n.m.r. spectra of two secondary fungal metabolites of related structure, aflatoxin B₁ and sterigmatocystin, have been completely assigned. The distribution pattern of acetate units has been determined from ¹³C n.m.r. spectra of aflatoxin B₁ derived from singly and doubly labelled [¹³C]acetate. These results and other published data on ¹³C-labelled sterigmatocystin agree with a biosynthetic scheme based on a C₂₀ polyketide precursor.