Differences in α1-adrenoceptor mechanisms for phenylephrine and tizanidine in rabbit thoracic aorta and common iliac artery
- 1 December 1991
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 69 (12) , 1819-1824
- https://doi.org/10.1139/y91-269
Abstract
Based on affinity for WB4101 and susceptibility to chloroethylclonidine, we evaluated the subtype of α1-adrenoceptors activated by phenylephrine (a full agonist) and tizanidine (a partial agonist). The rabbit thoracic aorta and common iliac artery contain both α1A- and α1B-adrenoceptors, but the α1B-subtype may be more predominantly in the common iliac artery than in the thoracic aorta. In rabbit thoracic aorta and common iliac artery, phenylephrine induced contraction through both α1A-and α1B-subtypes and tizanidine through only the α1A-subtype. The subtype activated by phenylephrine may be partly different from that activated by tizanidine in the preparations used herein.Key words: rabbit thoracic aorta, rabbit common iliac artery, α1A-subtype, α1B-subtype, α1-adrenoceptor mechanism.Keywords
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