Solid‐phase synthesis of oxytocin using iodotrichlorosilane as Boc deprotecting agent
- 1 April 1995
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 45 (4) , 377-379
- https://doi.org/10.1111/j.1399-3011.1995.tb01051.x
Abstract
Deprotection of the tert-butoxycarbonyl group during solid-phase synthesis of peptides can be conveniently and efficiently carried out using a neutral reagent, silicon tetrachloride/sodium iodide (iodotrichlorosilane). This simple and rapid method has been advantageously employed during the solid-phase synthesis of the pituitary hormone, oxytocin.Keywords
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