Effects of ethanol on sodium, 3-O-methyl glucose, andl-alanine transport in the jejunum

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Abstract
Effects of ethanol on Na+, Cl−, 3-O-methyl glucose (3-O-MG), andl-alanine fluxes were studied in the isolated rabbit jejunal mucosa. Ethanol (3% v/v present on both sides of the mucosa) decreased electrical potential difference (PD), short-circuit current (Isc) and inhibited active transport of Na+, 3-O-MG, andl-alanine. This concentration also increased the permeability of the mucosa for Cl−, 3-O-MG, andl-alanine. Ethanol at 5.4% potentiated the effects on PD, Isc, and the permeability for electrolytes and organic substances. These effects of ethanol could not be fully explained by an osmotic action.