Accessory Cell Paradox: Monocytes Enhance or Inhibit Lectin‐Mediated Human T‐Lymphocyte Proliferation Depending on the Choice of Mitogen

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Abstract
Monocytes suppressed the mitogenic response of human T lymphocytes to the lectin from Datura stramonium but enhanced the mitogenic response of the same lymphocytes to wheat germ agglutinin under identical culture conditions. The inhibitory action was probably cell-mediated, but was not the result of cytotoxicity. The stimulative activity could be replaced by cell-free conditioned medium.