An Autopsy Case of Crow‐Fukase (POEMS) Syndrome with a High Level of IL‐6 in the Ascites Special Reference to Glomerular Lesions

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Abstract
A 58‐year‐old man developed polyneuropathy, or‐ganomegaly, gynecomastia, skin pigmentation, and multiple myeloma (IgG‐Λ type). Although transient clinical improvement was obtained with prednisolone and cyclophosphamide, his general condition deteriorated progressively, and he died 3 years after onset. Lymph nodes showed angiofollicular hyperplasia, and the sural nerve revealed segmental demyellnation. At autopsy, the glomeruli were enlarged and showed mild mesangial cell proliferation with segmental mesangiolysis and proliferation of endothellal cells forming abnormal vessels. The massive volume of ascites contained a high level of inter‐leukin‐6 (IL‐6). IL‐6, a multifunctlonal cytokine, may be the pathogenic factor which induces the various clinical symptoms and pathological features of Crow‐Fukase (POEMS) syndrome. Acta Pathol Jpn 42: 651–656,1992.