Anticonvulsant and Toxic Effects of Alpha‐Phenyl=Butyryl Urea

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Abstract
Alpha-phenylbutyrylurea (PBU), the ethyl analog of Phenurone and the aliphatic analog of phenobarbital, was a potent anticonvulsant against artificially induced convulsions in laboratory animals. Further, it was chronically non-toxic in effective doses. In a group of 10 institutionalized patients with severe epilepsy, this drug appeared to be effective in controlling grand mal seizures. However, it produced severe toxic effects when doses necessary to bring about adequate control were given. PBU was not given an adequate trial in psychomotor epilepsy, but from the evidence now available it appears that it increases the frequency of psychomotor attacks, PBU was not tested in petit mal epilepsy. The extreme toxicity of alpha-phenylbutyrylurea at effective anticonvulsant dosage levels precludes its use as a therapeutic agent in epilepsy.

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