Comparison of Lung Volume Measurements by Single Breath Helium and Multiple Breath Nitrogen Equilibration Methods in Normal Subjects and COPD Patients
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Respiration
- Vol. 49 (1) , 52-60
- https://doi.org/10.1159/000194859
Abstract
The validity of the single breath helium dilution method for accurate measurement of the total lung capacity (TLC) was investigated. Comparison was made with the multiple breath nitrogen equilibration technique in 22 normal subjects and 37 patients with chronic obstructive pulmonary disease (COPD). The single breath method underestimated the TLC in all the normal individuals and 33 of 37 patients with COPD. Possible explanations for the falsely low lung volumes include uneven distribution of inspired air due to closing volumes and induced bronchoconstriction.Keywords
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