Cefotaxime Kinetics after Multiple-Dose Intramuscular Study in Healthy Volunteers

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Abstract
The pharmacokinetics of cefotaxime after repeated doses of intramuscular injections were studied in 8 healthy volunteers receiving 1 g cefotaxime every 8 h for 6 days. Mean peak serum level after the first 1 g intramuscular dose was 26.8 ± 6.4 μg/ml and the peak serum concentration was reached within 75 min. The half-life of cefotaxime was 1.35 ± 0.33 h and the total apparent clearance 263 ± 63 ml/min. After the last injection (day 6), the mean peak serum level reached 19.1 ± 3.2 μg/ml and the areas under the curve were significantly lower than on day 1. No body accumulation of the drug could be detected. Serum levels of cefotaxime monitored throughout the study 5 min prior to and 30 min after the intramuscular injection were found above the minimum inhibitory concentration for most aerobic gram-positive and gram-negative sensitive organisms.