Inhibition of murine granulopoiesis in vitro by dexamethasone

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Abstract
The effect of dexamethasone on mouse bone marrow granulocyte‐monocyte precursor cells (CFU‐C) was studied in vitro. Dexamethasone inhibited colony formation in the presence of maximally stimulating concentrations of colony‐stimulating activity. A mean colony reduction of 55% occurred at 109 M dexamethasone and inhibition was observed at concentrations as low as 10−12 M. The dexamethasone suppression could be abrogated by progesterone. These studies provide evidence that the committed granulocyte‐monocyte stem cell has a glucocorticoid receptor mechanism that when activated results in inhibition of cellular proliferation in vitro.

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