Effects of Cortisone Acetate and 17-Hydroxycorticosterone Acetate on the Adrenalectomized Rhesus Monkey

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Abstract
The effects of cortisone acetate and 17-hydro-corticosterone acetate were investigated in bilaterally adrenalectomized rhesus monkeys. Body weights, hematocrit and the blood levels of glucose, non-protein nitrogen, amino acid nitrogen, inorganic phosphorus, K, Na and chloride were determined at frequent intervals before and during the periods of hormone administration. At the dose levels studied, no major qualitative and quantitative differences between effects of cortisone acetate and hydrocortisone acetate could be demonstrated except that cortisone acetate by virtue of its greater rate of absorption from injection sites elicited a physiological response more rapidly than hydrocortisone acetate. Daily doses of 3 mg/kg were found to afford complete replacement with regard to the criteria employed although glucose tolerance was indicative of slight hyopglycemia. Two mg/kg/day failed to prevent electrolyte derangements and weight loss in some animals but was effective in maintaining other blood constituents within normal range. Doses of 1 mg/kg/ day or less were, with 1 exception, ineffective in maintaining the life of adrenalectomized monkeys. These lower doses of cortisone and hydrocortisone did exert transient beneficial effects from which escapes were observed although the hormone regime was not altered.

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