Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries
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Open Access
- 1 January 2008
- journal article
- Published by Springer Nature in Immunome Research
- Vol. 4 (1) , 2
- https://doi.org/10.1186/1745-7580-4-2
Abstract
It has been previously shown that combinatorial peptide libraries are a useful tool to characterize the binding specificity of class I MHC molecules. Compared to other methodologies, such as pool sequencing or measuring the affinities of individual peptides, utilizing positional scanning combinatorial libraries provides a baseline characterization of MHC molecular specificity that is cost effective, quantitative and unbiased.Keywords
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