Interobserver agreement on Poser’s and the new McDonald’s diagnostic criteria for multiple sclerosis

Publisher Website
Google Scholar
Abstract
We assessed the interobserver agreement on the diagnosis of multiple sclerosis (MS) in a study sample consisting of 41 MS (15 relapsing -remitting, two secondary progressive, five primary progressive and 19 presenting their first clinical attack) and three non-MS cases. C linical and paraclinical information was recorded in standardized forms. Four neurologists were asked to make a diagnosis using Poser’s and McDonald’s criteria and to assess MRI scans according to the McDonald’s guidelines. In terms of the kappa statistic (k), we found a moderate agreement on the overall diagnosis using both Poser’s and McDonald’s criteria (k, respectively, 0.57 and 0.52). A s for distinct diagnostic categories, we observed a moderate to substantial agreement for the three McDonald categories (range of k values 0.49-0.64) and a fair to substantial agreement for the nine Poser categories (range of k values 0.37-0.67). Taking into account clinical information, the agreement on dissemination over time was substantially higher (k=0.69) than that found on dissemination over space (k=0.46). In contrast, for MRI assessment, the agreement for spatial dissemination was substantial (k=0.74) compared with the fair agreement (k=0.25) yielded by dissemination over time. The new McDonald’s criteria yield a good overall diagnostic reliability, and compare favourably with Poser’s classification in terms of agreement on distinct diagnostic categories.