Triton X-100 alters the resistance level of methicillin-resistant Staphylococcus aureus to oxacillin
Open Access
- 15 December 1995
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 134 (2-3) , 209-212
- https://doi.org/10.1016/0378-1097(95)00406-x
Abstract
We used population analysis to examine the effects of Triton X-100 on the level of resistance to oxacillin of 18 methicillin-resistant Staphylococcus aureus. In the presence of 0.02% Triton X-100, 17 formerly methicillin-resistiant strains exhibited enhanced sensitivity to oxacillin. One homogeneous isolate, KSAF1 was barely affected by the Triton X-100. Sensitivities of lysostaphin, 51 kDa N-acetylglucosaminidase and 62 kDa N-acetylmuramoyl-l-alanine amidase to heat-inactivated cells were not affected when the bacteria were grown in 0.02% Triton X-100. Our data, together with those of a previous study, suggested that Triton X-100 alters the resistance level of methicillin-resistant S. aureus by influencing a factor(s) other than PBPs, bacteriolytic enzymes, or femAB products.Keywords
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