Gastrointestinal Hormones and Insulin Secretion

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Abstract
When the subject was reviewed in this journal three years ago1 the conclusion was reached that the enhanced insulin release after ingestion of glucose, as compared with an intravenous application, is caused by hormones released from the intestinal tract. However, the available data did not indicate whether this insulin release after oral food intake was due to one of the known hormones (gastrin, secretin, cholecystokinin, serotonin or enteroglucagon) or to the combined action of more than one of these hormones or to a still unidentified insulin-releasing factor, hypothetically called "incretin." More work has been done in this field, and the . . .