Substitution of extracellular sodium ions blocks the voltage-dependent decrease of input conductance evoked by L-aspartate

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Abstract
The response of cultured spinal cord neurones to L-aspartic acid consists of membrane depolarization accompanied by an apparent voltage-dependent reduction in input conductance (Gm). Depolarizations evoked by this amino acid and the decrease in Gm were reduced or eliminated when cultured spinal cord neurones were superperfused with solutions where Na was substituted with choline or Tris. Responses to L-aspartate recovered rapidly upon return to the control (Na-containing solution). The voltage-dependent component of the response to L-aspartate is dependent upon the presence of external Na.