Carcinogenic Dose-Response Curve to Oral Diethylstilbestrol2

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Abstract
An attempt was made to determine the relationship of mammary tumor incidence in mice to the concentration of diethylstilbestrol in the diet. Intact C3H male and female mice and castrate strain A male mice were used. In C3H female mice 6.25 parts per billion (ppb) of diethylstilbestrol in the diet throughout life caused a significant increase in tumor formation over that found in the controls. Linear log dose-response curves with significant slopes were obtained in C3H female mice (25–500 ppb) and in strain A castrate male mice (12.5–1000 ppb). Average weight of ovaries from a sample of the C3H females decreased linearly between doses of 12.5 ppb and 500 ppb.

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