A highly conserved sequence on the short arm of chromosome 7 detects multiple polymorphisms
- 1 December 1988
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 81 (1) , 23-25
- https://doi.org/10.1007/bf00283723
Abstract
We have isolated a human DNA fragment (laboratory acronym G98) that detects related sequences in mammals, chicken and Drosophila DNAs. This sequence has been mapped to human chromosome 7 p14-p15 by in situ hybridization. Probe G98 recognizes an insertion-deletion type polymorphism, with allelic frequencies of about 0.5, which can be detected with at least six different restriction enzymes. A second polymorphism, which can be detected in human DNA digested with TaqI, is in non-complete linkage disequilibrium with the first polymorphism. About 70% of the individuals analysed have been found to be heterozygous at this locus.This publication has 8 references indexed in Scilit:
- Genetic linkage map of human chromosome 7 with 63 DNA markers.Proceedings of the National Academy of Sciences, 1987
- Genetic Mapping of the Human X Chromosome: Linkage Analysis of the q26-q28 Region That Includes the Fragile X Locus and Isolation of Expressed SequencesCold Spring Harbor Symposia on Quantitative Biology, 1986
- Localization of cystic fibrosis locus to human chromosome 7cen–q22Nature, 1985
- A closely linked genetic marker for cystic fibrosisNature, 1985
- A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7Nature, 1985
- Regional localization on the human X chromosome and polymorphism of the coagulation factor IX gene (hemophilia B locus).Proceedings of the National Academy of Sciences, 1984
- Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemiaNature, 1983
- Cloning of a representative genomic library of the human X chromosome after sorting by flow cytometryNature, 1981