C-Reactive Protein as a Predictor for Incident Diabetes Mellitus Among Middle-aged Men

Top Cited Papers
Open Access
Publisher Website
Google Scholar
Abstract
C-REACTIVE PROTEIN (CRP), a sensitive marker of systemic inflammation, has been shown to be increased in patients with type 2 diabetes mellitus.1,2 In addition, CRP levels are elevated in individuals with features of the metabolic syndrome3-10 and with cardiovascular disease.3,11 Although several prospective studies12,13 have also consistently shown that CRP predicts myocardial infarction and other cardiovascular end points, little is known about the association between CRP and incident type 2 diabetes mellitus. Given the hypothesis that type 2 diabetes mellitus and atherosclerotic vascular disease may arise from a "common soil"14,15 and that inflammation may be an important antecedent factor for both diseases,16,17 we assumed that CRP, the classic acute-phase protein, might be related to incident diabetes mellitus. To further elucidate the mechanisms involved in the pathogenesis of type 2 diabetes, we examined the association between CRP and diabetes mellitus prospectively in a large cohort of men from the general population.

This publication has 32 references indexed in Scilit: