Lack of Effect of UPD, UDPG, and Glucosamine on Platelet Reactions with Collagen

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Abstract
Using a technique for quantitating platelet adherence to a surface coated with repolymerized acid-soluble collagen, suspensions of washed platelets from pigs or humans showed no significant inhibition or enhancement of adherence by UDP or UDPG (1 or 10 mM) in the presence of 1.5 .mu.M MnCl2 at pH 7.35. Glucosamine (1 mM) did not inhibit adherence of platelets to a collagen-coated surface when it was present during the reaction of the platelets with the collagen-coated surface, nor when it was present at a concentration of 10 mm during the polymerization of the collagen on the surface. UDP, UDPG or glucosamine (0.8 mM) had no effect on collagen-induced aggregation in suspensions of washed platelets from humans or pigs.