Genomic Imprinting and Its Clinical Implications

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Abstract
What do rare conditions such as the Prader—Willi and Angelman syndromes have to do with the real world of the busy practitioner? They seem esoteric and exotic, and yet these rare syndromes are windows into the world of a newly recognized phenomenon of inheritance called genomic imprinting. Over the past few years, work in many different fields has demonstrated that there are "parent-of-origin" effects on the function of chromosomes and genes.1 , 2 In other words, for some genes and for parts of some chromosomes, it makes a difference whether they are inherited from the mother or from the father. The report . . .