Opioid-Induced Mast Cell Activation and Vascular Responses Is Not Mediated by ??-Opioid Receptors: An In Vivo Microdialysis Study in Human Skin
- 1 February 2004
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 98 (2) , 364-370
- https://doi.org/10.1213/01.ane.0000097168.32472.0d
Abstract
Activation of mast cells and the systemic release of histamine is a common side effect of opioids. Nevertheless, fentanyl and its derivatives show only a slight activation of mast cells with a subsequent liberation of histamine and tryptase. In this study, we used intradermal microdialysis to assess whether this stimulatory effect of opioids on mast cells depends on the activation of opioid receptors. This new approach allowed us to measure the dose-dependent release of histamine and tryptase from mast cells and the subsequent vascular and sensory effect without systemic side effects in volunteers. The opiate codeine and the synthetic opioids meperidine, fentanyl, alfentanil, sufentanil, remifentanil, buprenorphine, and the opioid antagonist naloxone were tested. Only codeine and meperidine induced mast cell activation with the release of tryptase and histamine, leading to protein extravasation, flare reactions, and itch sensations. Because naloxone did not attenuate these effects, it is unlikely that mu-opioid receptors are involved in the activation of mast cells. Opioid effects on mast cells were assessed using intradermal microdialysis. Mast cell activation was seen with codeine and meperidine; no other opioid induced degranulation. Therefore, histamine release seen at large concentrations of potent micro agonists is caused by an unspecific effect rather than an activation of opioid receptors.Keywords
This publication has 19 references indexed in Scilit:
- Allergic reactions to drugs: Implications for perioperative careJournal of PeriAnesthesia Nursing, 2002
- Itching after intrathecal morphine. Incidence and treatmentEuropean Journal of Anaesthesiology, 2000
- Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysisNeuroscience Letters, 1997
- Quantitative measurement of extracellular histamine concentrations in intact human skin in vivo by the microdialysis technique: methodological aspectsAllergy, 1997
- Drug allergies in the surgical populationCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1994
- Mechanisms of activation of human mast cells and basophils by general anaesthetic drugsAnnales Françaises dʼAnesthésie et de Réanimation, 1993
- Substances anesthésiques responsables de chocs anaphylactiques. Enquête multicentrique françaiseAnnales Françaises dʼAnesthésie et de Réanimation, 1990
- Wheal and Flare Responses to Opioids in HumansAnesthesiology, 1989
- Comparison of Histamine Release in Human Skin Mast Cells Induced by Morphine, Fentanyl, and OxymorphoneAnesthesiology, 1985
- Induction of human cutaneous mast cell degranulation by opiates and endogenous opioid peptides: Evidence for opiate and nonopiate receptor participationJournal of Allergy and Clinical Immunology, 1984