Quantification of Trabecular Bone with Low Dose Computed Tomography

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Abstract
Computed tomography (CT) has the potential of providing a precise quantification of trabecular bone. A special purpose, low dose CT system for applications at peripheral measuring sites was developed. With this system, the quantification of trabecular bone can be achieved with a reproducibility on the order of 0.3%. It was used successfully in pilot studies of immobilization osteoporosis in children and adults on a week-by-week basis. The method is being used in a preliminary investigation of bone loss in women in order to differentiate normal changes from changes due to postmenopausal osteoporosis. Intervals of 3 mo. may be adequate for following the natural course of osteoporosis or its response to therapy on an individual basis.

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