Human Cryptosporidiosis: An Update With Special Emphasis on the Situation in Europe

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Abstract
The genus Cryptosporidium consists of different species and genotypes which infect a wide range of hosts, including humans. The parasite is ubiquitous and lack of differentiation between the species and strains has made it difficult to track down sources of human and animal infections. Genetic analysis of strains and isolates has led to the redescription of Cryptosporidium with special consideration of the host specificity and possible ways of transmission to humans. Infection with the small oocysts usually occurs directly by faecal-oral transmission, water- or food-borne. In Europe water from different sources is frequently contaminated with oocysts. Generally, humans are most frequently infected with C. hominis in an anthroponotic cycle (especially in cases of infections imported from highly endemic (sub-) tropical regions) and the animal genotype (type II) of C. parvum in a zoonotic cycle which seems to play a major role in autochthonous infections in Switzerland, the UK and probably other European countries. Other species (such as C. felis or the avian species C. meleagridis and C. baileyi) and genotypes are rare in humans and mostly restricted to immunocompromised individuals who are highly susceptible to serious opportunistic cryptosporidial infections.

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