Failure to demonstrate vasopressor material in salt hypertensive rats

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Abstract
Rats with acute or chronic salt hypertension were assayed for the presence of circulating vasopressor material. The technique consisted of transferring blood from the hypertensive rats to normal recipient rats and measuring the rise in blood pressure of the recipients. The blood of salt hypertensive animals proved to be uniformly devoid of vasopressor activity during the entire course of hypertension. The negative assays matched those obtained with normotensive blood from sham-operated rats and were in sharp contrast to the positive assays in early renal hypertension. The results indicate that salt hypertension is not mediated through a humoral pressor mechanism.