Mosquito host influences on development of filariae

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Abstract
A brief review is presented of the literature relating to factors which limit the capacity of filariae to develop in mosquitoes, with particular emphasis on immune mechanisms. Most insects respond to bacterial infection by the production of potent antibacterial proteins, but little is known of this aspect of the immune response in mosquitoes or of the possible influence of immune proteins on the fate of filarial infections in mosquitoes. A summary account is given of recent experiments with the mosquito Aedes aegypti which involve passive transfer of immune haemolymph together with its in vitro assay and SDS-PAGE examination for induced proteins. These experiments demonstrate the production, in response to inoculation with Brugia pahangi, Escherichia coli, and various components of microbial cell walls, of haemolymph factors which are protective against filarial infection. It remains to be seen whether mosquitoes can produce a specific protective response to infection with eukaryotic organisms such as filaria that is distinctive from that mobilized against bacteria.