Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

This publication has 21 references indexed in Scilit:

• Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor
  The Journal of Pharmacology and Experimental Therapeutics, 2004
• The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B₄ in a novel human whole blood assay
  British Journal of Pharmacology, 1999
• PDE4 inhibition and a corticosteroid in chronically antigen exposed conscious guinea-pigs
  Clinical and Experimental Allergy, 1998
• Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma
  Canadian Journal of Physiology and Pharmacology, 1998
• CDP840
  Cell Biochemistry and Biophysics, 1998
• The Role of Phosphodiesterase Enzymes in Allergy and Asthma
  Published by Elsevier ,1998
• The Multienzyme PDE4 Cyclic Adenosine Monophosphate–Specific Phosphodiesterase Family: Intracellular Targeting, Regulation, and Selective Inhibition by Compounds Exerting Anti-inflammatory and Antidepressant Actions
  Published by Elsevier ,1998
• Phosphodiesterases 4 Inhibitors
  Published by Elsevier ,1998
• The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4
  British Journal of Pharmacology, 1996
• The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep
  European Journal of Pharmacology, 1992