Synthesis of 3,6-bis(aminoalkoxy)acridines and their effect on the immune system
- 1 December 1983
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 26 (12) , 1710-1715
- https://doi.org/10.1021/jm00366a010
Abstract
A series of 3,6-bis(aminoalkoxy)acridines (2) was prepared and shown to have a protective antiviral effect against an interferon-sensitive virus (Columbia SK) and to partially restore an antibody response to a T-cell-dependent antigen in leukemic immunosuppressed mice. The presence of circulating interferon and the stimulation of natural killer cell activity in mice was observed for 21.Keywords
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