The role of altered bile acid metabolism in the steatorrhea of experimental blind loop.

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Abstract
A jejunal blind loop was produced surgically in 12 dogs and steatorrhea of up to 56% of dietary fat occurred within 2 to 7 mo. Deconjugation of isotopic bile acids was demonstrated within the small intestine and the blind loop coincident with alteration in ring substitution. After a fat-containing meal, 2.2 [plus or minus] 5.0% of jejunal content lipid was in micellar phase in blind loop dogs compared to 56. 5 [plus or minus] 35. 6% in control animals. Steatorrhea was corrected by orally administered sodium taurocholate. Altered bile acid metabolism may play a role in impaired fat absorption by interfering with optimal intraluminal micelle formation.