Relative Sensitivity of Chromosomes to Neutrons and X-Rays
- 1 February 1945
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 31 (2) , 84-90
- https://doi.org/10.1073/pnas.31.2.84
Abstract
Rats with Walker 256 carcinoma and a lymphosarcoma were subjected to x-rays or neutrons and the % of normal anaphases counted in prepns. of the tissue. Chromosomes of the carcinoma are more sensitive than those of the lymphosarcoma. The latter respond more like those of the mouse lymphoma. The ratio of neutron to x-ray efficiency n/x is approx. 6 at all time intervals in the lymphosarcoma, whereas in the carcinoma n/x increase from 6 at 3 hrs. to 10.8 at 24 hrs. Evidently there are physiol. differences in the chromosomes of 2 different tissues in the same sp. and it cannot be assumed that chromosomes remain unaltered during normal ontogeny and during de-differentiation in carcinogenesis.Keywords
This publication has 3 references indexed in Scilit:
- Relative Effects of X-Rays and Neutrons on Chromosomes in Different Parts of the “Resting Stage”Proceedings of the National Academy of Sciences, 1942
- THE BEHAVIOR OF X-RAY INDUCED CHROMOSOMAL ABERRATIONS IN ALLIUM ROOT TIP CELLSGenetics, 1941