Generation and Characterization of a Defined Mutant of Streptococcus suis Lacking Suilysin

Open Access

1 April 2001

journal article
research article
Published by American Society for Microbiology in Infection and Immunity

Vol. 69 (4) , 2732-2735
https://doi.org/10.1128/iai.69.4.2732-2735.2001

Abstract

A defined allelic-replacement mutant of the sly gene, encoding a thiol-activated cytolysin, from a European isolate of Streptococcus suis serotype 2 was generated and characterized. Unlike the parental strain, it is nonhemolytic, noncytotoxic for cultured macrophage-like cells, avirulent in a mouse infection model, yet only slightly attenuated in a porcine model of systemic infection.

Keywords

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