DETECTION OF AUTOANTIBODIES TO THE 90 kDa HEAD SHOCK PROTEIN IN SYSTEMIC LUPUS ERYTHEMATOSUS AND OTHER AUTOIMMUNE DISEASES
- 1 October 1994
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 33 (10) , 923-926
- https://doi.org/10.1093/rheumatology/33.10.923
Abstract
Expression of the highly conserved 90 kDa heat shock protein (Hsp90) is elevated in the peripheral blood mononuclear cells of approximately 25% of patients with SLE. Conflicting data have been published about the frequency of antibodies to Hsp90 with the previous methodology using a complex Western blot system. We now describe an ELISA to measure autoantibodies to Hsp90 and Hsp70 in SLE patients, healthy controls and patients with a variety of autoimmune rheumatic diseases, IgG and IgM antibodies were elevated in 26 and 35% of SLE patients, respectively. These results show autoantibodies to Hsp90 (but not Hsp70) are elevated in a significant proportion of patients with SLE (PP<0.02).Keywords
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