Agouti-related peptide–expressing neurons are mandatory for feeding
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- 11 September 2005
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 8 (10) , 1289-1291
- https://doi.org/10.1038/nn1548
Abstract
Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.Keywords
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