Total synthesis of α- and β-himachalene by an intermolecular Diels–Alder approach
- 1 February 1981
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 59 (3) , 601-608
- https://doi.org/10.1139/v81-088
Abstract
A total synthesis of α-himachalene (2) and β-himachalene (3) has been achieved in eleven steps and in an effective overall yield of 21% from 4,4-dimethyl-2-cyclohexenone (4). The synthesis involves keto ester 7 as a key intermediate which is conveniently prepared by the Diels–Alder addition of dienone ester 6 to isoprene.This publication has 5 references indexed in Scilit:
- Studies in sesquiterpenes—LIVTetrahedron, 1977
- Studies in sesquiterpenes—XXIXTetrahedron, 1968
- Studies in sesquiterpenes—XXXIIITetrahedron, 1968
- Studies in sesquiterpenes—XXXIITetrahedron, 1968
- Studies in sesquiterpenes—XXXITetrahedron, 1968