EFFECTS OF NITROGEN MUSTARD ON THE BONE MARROW IN POLYCYTHEMIA VERA

1 October 1950

journal article
research article
Published by American College of Physicians in Annals of Internal Medicine

Vol. 33 (4) , 841-853
https://doi.org/10.7326/0003-4819-33-4-841

Abstract

Significant reduction in the percentage of normoblasts may occur between 24 and 48 hrs., and may become marked 72-120 hrs. after the initial injn. of nitrogen mustard, with progressive parallel decrease of the most immature cells of the erythroid series. When the reduction in the % of normoblasts was most marked, it was seen to be a part of a general hypoplasia of the bone marrow, but significant reduction in the % of erythrocyte precursors may occur in the absence of marked general hypoplasia.

Keywords

POLYCYTHEMIA VERA
MECHLORETHAMINE
BONE MARROW

This publication has 2 references indexed in Scilit:

NITROGEN MUSTARD THERAPY
JAMA, 1946
THE CELLULAR COMPOSITION OF NORMAL BONE MARROW AS OBTAINED BY STERNAL PUNCTURE
Physiological Reviews, 1944