Synthesis of 7-O-(2,6-dideoxy-2-fluoro-4-O-(3-fluorotetrahydropyran-2-yl)-.ALPHA.-L-talopyranosyl)daunomycinone.

1 January 1992

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 45 (3) , 355-362
https://doi.org/10.7164/antibiotics.45.355

Abstract

7-O-[2,6-Dideoxy-2-fluoro-4-O-(3-fluorotetrahydropyran-2-yl)-alpha -L- talopyranosyl]daunomycinones (7a-7c) have been prepared by condensation of 3'-O-benzoyl derivative of 7-O-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)daunomycinone with 2,3-difluorotetrahydropyran as the key reaction. Antitumor activities of these compounds are described.

Keywords

FLUOROTETRAHYDROPYRAN
DIDEOXY
KEY REACTION
7A 7C
FLUORO ALPHA
ANTITUMOR ACTIVITIES
BENZOYL DERIVATIVE

This publication has 0 references indexed in Scilit: