Cross-coupling reaction of chloropyridazines and grignard reagents with nickel-phosphine complexes: Alkylation and arylation of pyridazines.
- 1 January 1978
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 26 (8) , 2550-2554
- https://doi.org/10.1248/cpb.26.2550
Abstract
Alkyl- and arylpyridazines have been prepared by cross-coupling reaction between chloropyridazines and Grignard reagents in the presence of nickel-phosphine complexes (as catalysts). Hitherto unaccessible naphthyl- and thienylpyridazines have been obtained.Keywords
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